Titre :
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Proceedings of Health Conference'97 - Great Lakes/St. Lawrence. Assessment of prenatal exposure to PCBs from maternal consumption of Great Lakes fish : An analysis of PCB pattern and concentration. (1999)
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Auteurs :
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P. STEWART ;
B. BUSH ;
T. DARVILL ;
Christopher-T DE ROSA, éd. ;
Andrew-P GILMAN, éd. ;
E. LONKY ;
J. Pagano ;
J. REIHMAN ;
Zemoria-A ROSEMOND, éd. ;
Agency for Toxic Substances and Disease Registry. Us Department of Health and Human Services. Atlanta. GA. USA ;
Center for Neurobehavioral Effects of Environmental Toxics and Department of Psychology. State University of New York at Oswego. Oswego. NY. USA ;
Health Canada. CAN ;
Health Conference'97 - Great Lakes/St. Lawrence. (12/05/1997; Montréal. PQ. CAN)
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Type de document :
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Article
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Dans :
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Environmental research (vol. 80, n° 2, 1999)
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Pagination :
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S87-S96
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Langues:
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Anglais
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Mots-clés :
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PCB
;
Contamination
;
Nouveau né
;
Homme
;
Femme
;
Consommation alimentaire
;
Poisson
;
Amérique
;
Etats Unis
;
Taux
;
Cordon ombilical
;
Grossesse
;
Facteur risque
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST Odsz2R0x. Diffusion soumise à autorisation]. The current study was designed to assess the pattern and concentration of prenatal PCB exposure in the newborns of women who consumed Great Lakes fish. We compared the pattern and concentration of umbilical cord blood PCBs of 145 women who reported never having consumed Great Lakes fish to 134 women who reported consuming at least 40 PCB-equivalent fish lbs of Great Lakes fish in their lifetime (Lonky et al., 1996). Although the average levels of total PCBs in cord blood were exceedingly low (approximately 1.0ppb), the data clearly indicated that both the proportion (mol%) and the absolute concentration (ppb) of the most heavily chlorinated and persistent PCB homologues (homologues C17-C19) were markedly elevated in the cord blood of fish eaters. This effect grew markedly as a function of the total PCBs detected in the sample. Moreover, the concentration of the most heavily chlorinated PCB homologues was significantly dependent on how recently the fish were consumed relative to pregnancy. The order of highly chlorinated PCB concentration was consumed fish throughout pregnancy>consumed fish up until pregnancy>stopped consuming fish in 1984>never consumed Lake Ontario fish. In contrast, PCB homologues of light (Cll-C13) or moderate (C14-C16) chlorination were unrelated to fish consumption. Analysis of the relationship between the PCB homologues in cord blood and their homologues in breast milk provided further converging evidence of these findings. (...)
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