Titre :
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Congenital cytomegalovirus infection in a northern Italian region. (1998)
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Auteurs :
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M. BARBI ;
S. BINDA ;
D. CLERICI ;
V. PRIMACHE ;
Institute of Virology. University of Milan. Milan. ITA ;
Neocmv Group. INC
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 14, n° 8, 1998)
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Pagination :
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791-796
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Langues:
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Anglais
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Mots-clés :
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Italie
;
Europe
;
Nouveau né
;
Homme
;
Epidémiologie
;
Prévalence
;
Dépistage
;
Virose
;
Infection
;
Virus
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Résumé :
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[BDSP. Notice produite par INIST Pf92R0xk. Diffusion soumise à autorisation]. Knowledge of the prevalence of congenital cytomegalovirus infection is necessary to evaluate the need for prevention. We performed a multicentre one-year study involving 11 neonatology divisions to ascertain the prevalence in Lombardy. Cytomegalovirus was isolated by culturing saliva samples from all babies born (n=1268) of two 15-day sample periods and from 185 neonates with suspected congenital CMV based on clinical and laboratory findings and the history. The overall prevalence of congenital infection was 0.47% (6/1268) in the sample period group and 5% (9/185) in the second group. Clinical monitoring revealed sequelae in two of three children with symptomatic infection and no asymptomatic child at age two years. In a subgroup of 205 babies including 14 of the infected infants we also evaluated a test to detect cytomegalovirus DNA in the Guthrie cards obtained in neonatal screening for genetic and metabolic disorders. The test's sensitivity was 100% and specificity 98.5%, encouraging its use for early identification of infected neonates and for large epidemiological studies.
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