Résumé :
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[BDSP. Notice produite par INIST HzR0xAeX. Diffusion soumise à autorisation]. To investigate effects of smoking, aromatic amines (AAs), and chromates (CRs) on T lymphocyte subpopulations, we measured CD3+CD4+and CD8+T lymphocytes in the peripheral blood of 33 nonexposed workers, 25 AA-use workers, 27 AA-production workers, and 19 CR workers (all subjects were males). The number of CD4+T lymphocytes in smokers of nonexposed workers was significantly larger than that of the nonsmokers ; also, the numbers of CD4+and CD3+T lymphocytes in smokers of each group of AA-production and AA-use workers were significantly larger than those in nonsmokers. Numbers of CD4+and CD3+T lymphocytes in nonsmokers of AA-production and CR workers were significantly smaller than those in nonsmokers of nonexposed workers ; the number of CD8+T lymphocytes in nonsmokers of CR workers was significantly smaller than that in nonsmokers of nonexposed workers. This cross-sectional study suggests that (1) smoking increases CD4+ (and CD3+) T lymphocytes in all categories of workers except for CR workers ; (2) exposure to CRs and AAs decreases CD4+ (and CD3+) T lymphocytes ; (3) the magnitude of decrease in CD4+T lymphocytes is large among CR workers, intermediate among AA-production workers, and small among AA-use workers regardless of smoking status ; and (4) exposure to CRs also decreases CD8+T lymphocytes.
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