Titre :
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Sexual and non-sexual intrafamilial spread of hepatitis C virus : Intrafamilial transmission of HCV. (1998)
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Auteurs :
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N. SALTOGLU ;
R. BURGUT ;
I.H. DUNDAR ;
Y. TASOVA ;
Department of Biostatistics. Faculty of Medicine. University of Cukurova. Adana. TUR
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 14, n° 3, 1998)
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Pagination :
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225-228
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Langues:
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Anglais
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Mots-clés :
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Hépatite virale C
;
Virose
;
Infection
;
Famille
;
Homme
;
Prévalence
;
Virus
;
Appareil digestif [pathologie]
;
Foie [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST Nr10aR0x. Diffusion soumise à autorisation]. The rate of intrafamilial transmission of the hepatitis C virus (HCV) was investigated in 90 family members of 41 index patients with type C chronic liver disease. Antibody to HCV (anti-HCV) was detected by the EIA method (Abbott-Axsym Sys) and Hepatitis C virus RNA, by the polymerase chain reaction (Nested PCR). We also investigated the presence of anti-HCV in 350 healthy persons (control group). The subjects in the study included 38 spouses. 45 children and others (1 relative and 6 parents). Four family members including 3/38 (7.8%) spouses and 1 sister were found to be positive for anti HCV antibodies but none had HCV RNA. Anti-HCV was not detected in the children of index patients. The prevalence of anti-HCV in the families of index patients was significantly higher than in the controls (4.3% versus 0.85%) (p=0.0355). We concluded that the intrafamilial transmission of HCV is possible but occurs at a low rate.
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