Résumé :
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[BDSP. Notice produite par INIST iR0xu5Cs. Diffusion soumise à autorisation]. Context. - Hot weather taxes cardiovascular function and is associated with increased deaths from heart disease. Cocaine can cause hypertension, tachycardia, coronary vasospasm, arrhythmias, and increased core temperature. Objective-To determine the association between mortality from cocaine overdose and hot weather. Settlng-New York, NY. from 1990 through Design-Retrospective review of medical examiner cases from 1990 through 1995. Subjects-All fatal unintentional cocaine overdoses from 1990 through 1992 (n=1382) and all hyperthermia deaths of cocaine users (n=10) were used to identify a maximum daily temperature threshold above which mortality from cocaine intoxication increased. The study population consisted of all fatal unintentional cocaine overdoses from 1993 through 1995 in=2008) and 4 contemporaneous comparison groups that included fatal unintentional opiate overdoses (n=793), all other fatal unintentional overdoses (n=85), and a subset of homicides (n=4638) and fatalities from motor vehicle crashes (n=815). Main Outcome Measures. - The number of overdose deaths and the proportion of homicides and traffic fatalities with a positive cocaine toxicology test result on days with a maximum temperature above or below the temperature threshold. Results. - A threshold temperature of 31.1°C (88°F) was identified, above which the mean daily number of fatal cocaine overdoses increased steadily. On days with a maximum daily temperature of 31. (...)
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