Titre :
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Changes in T cell subpopulations in lead workers. (1998)
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Auteurs :
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F. SATA ;
S. ARAKI ;
N. KATSUNO ;
Y. MORITA ;
A. NAKATA ;
S. SAKURAI ;
T. TANIGAWA ;
Department of Public Health. Faculty of Medicine. University of Tokyo. Bunkyo ku Tokyo. JPN
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Type de document :
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Article
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Dans :
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Environmental research (vol. 76, n° 1, 1998)
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Pagination :
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61-64
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Langues:
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Anglais
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Mots-clés :
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Plomb
;
Exposition professionnelle
;
Médecine travail
;
Homme
;
Immunopathologie
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Résumé :
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[BDSP. Notice produite par INIST R0xuq1wp. Diffusion soumise à autorisation]. To investigate the effects of lead on the human immune system, we analyzed T cell subpopulations and B (CD19+) cells in peripheral blood in 71 male lead workers. They were engaged in manufacturing lead stearate in a chemical factory, aged 20 to 74 (mean 48) years. Their blood lead concentrations (PbB) were between 7 and 50 (mean 19) mug/dl. The control group consisted of 28 "healthy" male volunteers without a history of occupational exposure to lead or other hazardous substances, aged 33 to 67 (mean 55) years. In comparison with the controls, a significant reduction in the number of CD3+CD45RO+ (memory T) cells and a significant expansion in the percentage of CD8+cells in the lead workers were found. There was a significant positive correlation between the percentage of CD3+CD45RA+ (naive T) cells and PbB in the lead workers. It is suggested that CD45RO+memory T cells may be most susceptible to the effects of lead on T cell subpopulations.
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