Résumé :
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[BDSP. Notice produite par INIST R0x9bZMF. Diffusion soumise à autorisation]. Study objective-To describe the epidemiology of Epstein-Barr virus (EBV) among primary school children by testing saliva with a new EBV capsid antigen "G" antibody capture radioimmunoassay (GACRIA). Design-A population based sample of 7 year old schoolchildren were followed up at age 11. Setting-30 randomly chosen primary schools in Edinburgh, Scotland. Participants-552 schoolchildren. Measurements-Data on risk factors for infection were collected by questionnaire at ages 7 and 11. Saliva samples collected at age 11 were examined by GACRIA for evidence of previous infection with EBV. For 102 subjects, a second salivary specimen collected approximately one month after the first sample was available for testing as a measure of the repeatability of the method. Main results-Unequivocal results were found in 91% of samples and the repeatability of the test was good (K=0.71). Fifty six per cent of children had antibodies to EBV. In a logistic regression analysis, independent risk factors for infection were sharing a room (odds ratio 1.78,1.14,2.79), head of household's social class IV/V compared with I (odds ratio 2.87,1.08,7.34), and schools serving predominantly rented housing estates (odds ratio 2.3,1.09,4.84). Conclusion-This study is the first application of EBV viral capsid GACRIA to salivary samples. The method was successfully used to describe the epidemiology of EBV. (...)
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