Titre :
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Association of apolipoprotein E phenotype with plasma lipoproteins in African-American and white young adults : The CARDIA study. (1998)
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Auteurs :
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B.V. HOWARD ;
S.S. GIDDING ;
KIANG LIU . (.) ;
Department of Preventive Medicine. Northwestern University Medical School. Chicago. IL. USA
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 148, n° 9, 1998)
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Pagination :
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859-868
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Langues:
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Anglais
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Mots-clés :
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Lipoprotéine
;
Plasma sanguin
;
Appareil circulatoire [pathologie]
;
Ethnie
;
Epidémiologie
;
Facteur risque
;
Génétique
;
Homme
;
Etats Unis
;
Amérique
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST 4R0xOS12. Diffusion soumise à autorisation]. Apolipoprotein E phenotype (APOE phenotype) has been demonstrated to be a genetic determinant of cardiovascular disease. This atherogenicity may be a reflection of the association of APOE phenotype and plasma lipoprotein concentrations. The Coronary Artery Risk Development in Young Adults (CARDIA) Study affords the opportunity to assess the frequency of apolipoprotein E alleles in population-based samples of African Americans and whites in the United States and to compare the associations of APOE phenotype with lipoprotein and apoprotein concentrations. Data from 3,485 African-American and white men and women between the ages of 25 and 37 years who attended the fourth CARDIA Study examination in 1992-1993 were used in this analysis. African-American men and women had significantly higher frequencies of E2 and E4 phenotype and thus higher frequencies of *2 and *4 alleles (p
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