Résumé :
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[BDSP. Notice produite par INIST pzhkeR0x. Diffusion soumise à autorisation]. Background Increased brain tumour risk after head trauma suggested by case reports and clinical series has been previously studied epidemiologically with mixed results. An international multicentre case-control study investigated the role of head trauma from injury or sports participation in adult brain tumour risk. Methods In all, 1178 glioma and 330 meningioma cases were individually or frequency matched to 2236 controls. Only exposures that occurred at least 5 years before diagnosis and head injuries that received medical attention were considered. Results Risk for ever having experienced a head injury was highest for male meningiomas (odds ratio [OR]=1.5,95% confidence interval [CI] : 0.9-2.6) but was lower for'serious'injuries, i.e. those causing loss of consciousness, loss of memory or hospitalization (OR=1.2,95% CI : 0.6-2.3). Among male meningiomas, latency of 15 to 24 years significantly increased risk (OR=5.4,95% CI : 1.7-16.6), and risk was elevated among those who participated in sports most correlated with head injury (OR=1.9,95% CI : 0.7-5.3). Odds ratios were lower for male gliomas (OR=1.2,95% CI : 0.9-1.5 for any injury ; OR=1.1,95% CI : 0.7-1.6 for serious injuries) and in females in general. Conclusions Evidence for elevated brain tumour risk after head trauma was strongest for meningiomas in men. (...)
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