Résumé :
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[BDSP. Notice produite par INIST 1kgLzR0x. Diffusion soumise à autorisation]. As recognized precursor lesions to colorectal cancer, colorectal adenomatous polyps have been studied to enhance knowledge of colorectal cancer etiology. Although most of the known risk factors for colorectal cancer are also associated with the occurrence of colorectal adenomas, cigarette smoking has had a strong, consistent relationship with colorectal adenomas but is generally not associated with colorectal cancer. The explanation for this paradox is unknown. With data collected in 1986-1988 during a large case-control study based on colonoscopy results in New York City, New York, the authors investigated the possibility that the paradox may arise because subjects with colorectal adenomas were included in the control group of cancer case-control studies. The authors found a statistically significant increased risk between heavy cigarette smoking (smokers with 40 pack-years of smoking) and risk of adenoma (odds ratio (OR)=1.61,95% confidence interval (CI) 1.06-2.44). They saw no increased colorectal cancer risk from heavy cigarette smoking (OR=1.02,95% Cl 0.52-1.99) using a "manufactured" control group to simulate a typical unscreened, population-based control group. (...)
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