Titre : | Estimation of vaccine efficacy in the presence of waning : Application to cholera vaccines. (1998) |
Auteurs : | L.K. DURHAM ; J.D. CLEMENS ; M.E. HALLORAN ; Imjr LONGINI ; A. NIZAM ; M. RAO ; Department of Biostatistics. The Rollins School of Public Health. Emory University. Atlanta GA. USA ; Division of Epidemiology. Statistics. And Prevention. National Institute of Child Health and Human Development. National Institutes of Heath. Bethesda MD. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 147, n° 10, 1998) |
Pagination : | 948-959 |
Langues: | Anglais |
Mots-clés : | Vaccination ; Choléra ; Bactériose ; Infection ; Evaluation ; Efficacité ; Méthodologie ; Homme ; Etude comparée ; Bengla Desh ; Asie ; Prévention santé |
Résumé : | [BDSP. Notice produite par INIST lR0xBS7I. Diffusion soumise à autorisation]. The authors present a nonparametric method for estimating vaccine efficacy as a smooth function of time from vaccine trials. Use of the method requires a minimum of assumptions. Estimation is based on the smoothed case hazard rate ratio comparing the vaccinated with the unvaccinated. The estimation procedure allows investigators to assess time-varying changes in vaccine-induced protection, such as those produced by waning and boosting. The authors use the method to reanalyze data from a vaccine trial of two cholera vaccines in rural Bangladesh. This analysis reveals the differential protection and waning effects for the vaccines as a function of biotype and age. |