Titre :
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Determinants of serum adiponectin in persons with and without type 1 diabetes. (2007)
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Auteurs :
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David-M MAAHS ;
Dana DABELEA ;
ECKEL (Robert-H) : USA. Department of Medicine. University of Colorado Health Sciences Center. Denver. CO. ;
John-E HOKANSON ;
Gregory-L KINNEY ;
Adam KRETOWSKI ;
Lorraine-G OGDEN ;
Marian REWERS ;
Janet-K SNELL-BERGEON ;
Rpaul WADWA ;
Barbara Davis Center for Childhood Diabetes. University of Colorado Health Sciences Center. Aurora. CO. USA
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 166, n° 6, 2007)
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Pagination :
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731-740
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Langues:
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Anglais
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Mots-clés :
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Cardiopathie coronaire
;
Sérum
;
Maladie autoimmune
;
Epidémiologie
;
Homme
;
Glande endocrine [pathologie]
;
Immunopathologie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS D3i7R0xK. Diffusion soumise à autorisation]. Low levels of adiponectin have been related to coronary heart disease, but adiponectin is higher in persons with type 1 diabetes who have an increased rate of coronary disease. In the Coronary Artery Calcification in Type 1 Diabetes Study (2000-2002), the authors investigated potential determinants of elevated adiponectin levels in persons with type 1 diabetes and whether a difference exists compared with nondiabetic persons. Serum adiponectin was measured in 1,393 persons (sex : 48% male ; age : 38 (standard deviation : 9) years ; diabetes duration : 23 (standard deviation : 9) years ; 54% nondiabetic and 46% with type 1 diabetes). Determinants of log-transformed adiponectin levels were evaluated by multiple linear regression analysis with interaction terms to determine whether predictors of adiponectin levels differed by diabetes status. Adiponectin levels were higher in type 1 diabetic than nondiabetic persons (13.5 (standard deviation : 1.0) vs. 8.8 (standard deviation : 1.0) mug/ml ; p
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