Résumé :
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[BDSP. Notice produite par INIST rm2QR0x1. Diffusion soumise à autorisation]. Fractures in postmenopausal women may serve as a surrogate measure of bone density, reflecting long-term lower estrogen levels, and lower estrogen levels appear to be inversely associated with breast and endometrial cancer. Breast cancer cases aged 50-79 years (n=5,559) and endometrial cancer cases aged 40-79 years (n=739) were enrolled in a US case-control study in 1992-1994 to evaluate the relation between fractures and risk of breast and endometrial cancer. Controls for the breast cancer analysis (n=5,829) and the endometrial cancer analysis (n=2,334) were randomly selected from population lists (driver's license and Medicare files). Information on fracture history and other risk factors was obtained by telephone interview. Compared with women without a fracture in the past 5 years, the odds ratios for women with a history of fracture were 0.80 (95% confidence interval (Cl) : 0.68,0.94) for breast cancer and 0.59 (95% Cl : 0.40,0.89) for endometrial cancer. Height loss (>=2.5 cm) and recent fracture history were associated with the lowest risk of breast cancer (odds ratio=0.62,95% Cl : 0.46,0.83) and endometrial cancer (odds ratio=0.15,95% Cl : 0.05,0.43). These data suggest that the endogenous hormonal factors associated with increased fracture risk are also related to decreased breast cancer risk and, more strongly, to endometrial cancer risk. Am J Epidemiol 2001 ; 153 : 1071-8.
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