Résumé :
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[BDSP. Notice produite par INIST nuDkBR0x. Diffusion soumise à autorisation]. The authors evaluated the association between use of individual supplements of vitamins A, C, and E only and multivitamins and fatal non-Hodgkin's lymphoma in a large prospective mortality study of US men and women. During 14 years of follow-up (1982-1996), 1,571 non-Hodgkin's lymphoma deaths among 508,351 men and 1,398 non-Hodgkin's lymphoma deaths among 676,306 women were documented. Long-term regular use of individual supplements of vitamins A, C, and E only and multivitamins was unrelated to fatal non-Hodgkin's lymphoma among either men or women. The multivariate relative risks for men who used supplements for 10 or more years were 1.03 (95% confidence interval (Cl) : 0.54,2.00) for vitamin A supplements, 1.04 (95% Cl : 0.78,1.39) for vitamin C supplements, 1.06 (95% CI : 0.74,1.51) for vitamin E supplements, and 1.14 (95% Cl : 0.92,1.40) for multivitamins. The multivariate relative risks for women who used supplements for 10 or more years were 1.40 (95% Cl : 0.77,2.54) for vitamin A supplements, 1.19 (95% Cl : 0.89,1.60) for vitamin C supplements, 1.27 (95% Cl : 0.87,1.84) for vitamin E supplements, and 1.21 (95% Cl : 0.98,1.50) for multivitamins. All associations became weaker when vitamin supplements were mutually adjusted. These findings do not support an important relation between long-term regular use of individual supplements of vitamins A, C, and E only and multivitamins and fatal non-Hodgkin's lymphoma.
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