Résumé :
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[BDSP. Notice produite par INIST-CNRS SsTpRR0x. Diffusion soumise à autorisation]. Little is known about the factors that influence clearance of human papillomavirus (HPV), the primary cause of cervical carcinoma. A total of 227 women cytologically normal and HPV positive at baseline were identified from a population-based cohort of 1,995 Bogota, Colombia, women aged 13-85 years followed between 1993 and 2000 (mean follow-up, 5.3 years). HPV DNA detection and viral load determination were based on a GP5+/GP6+polymerase chain reaction enzyme immunoassay. Rate ratio estimates for HPV clearance were calculated by using methods for interval-censored survival time data. Analyses were based on 316 type-specific HPV infections. HPV 16 had a significantly lower clearance rate than infections with low-risk types (rate ratio (RR)=0.47,95% confidence interval (Cl) : 0.32,0.72), HPV types related to HPV 16 (types 31,33,35,52,58) had intermediate clearance rates (RR=0.62,95% CI : 0.47,0.94), and other high-risk types did not show evidence of slower clearance compared with low-risk types. Infections with single and multiple HPV types had similar clearance rates. There was no evidence of a dose-response relation between clearance and viral load. Observed was slower clearance in parous women (RR=0.64,95% CI : 0.47,0.89) and faster clearance in ever users of oral contraceptives (RR=1.38,95% Cl : 1.07,1.77).
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