Résumé :
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[BDSP. Notice produite par INIST-CNRS 8Ww1R0xD. Diffusion soumise à autorisation]. Context : Carotid artery intima-media thickness (IMT) is associated with cardiovascular risk factors and is recognized as an important predictive measure of clinical coronary atherosclerosis events in middle-aged and elderly populations. However, information on the association of carotid IMT in young adults with different risk factors measured in childhood, adulthood, or as a cumulative burden of each of the risk factors measured serially from childhood to adulthood is limited. Objective : To examine the association between carotid IMT in young adults and traditional cardiovascular risk factors measured since childhood. Design, Setting, and Participants : A cohort study of 486 adults aged 25 to 37 years from a semirural black and white community in Bogalusa, La (71% white, 39% men), who had at least 3 measurements of traditional risk factors since childhood, conducted between September 1973 and December 1996. Main Outcome Measure : Association of carotid IMT with risk factors, including systolic blood pressure, lipoprotein levels, and body mass index. Results : Male vs female (0.757 mm vs 0.719 mm) and black vs white (0.760 mm vs 0.723 mm) participants had increased carotid IMT (P<. for both in multivariable analyses significant predictors being top vs lower quartiles of carotid imt young adults were childhood measures low-density lipoprotein cholesterol level ratio corresponding to sd change specific age race and sex confidence interval body mass index or cl adulthood ldl-c high-density systolic blood pressure long-term cumulative burden hdl-c levels measured serially from adulthood. an increasing trend across was observed with a mean value mm those at the quartile conclusions : bmi predict adults. prevention implications these findings remains be explored.>
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