Titre : | Joint association of alcohol and folate intake with risk of major chronic disease in women. (2003) |
Auteurs : | . RUI JIANG ; Edward-L GIOVANNUCCI ; Frank-B HU ; Eric-B RIMM ; Bernard-A ROSNER ; Donna SPIEGELMAN ; Meir-J STAMPFER ; Walter-C Willett ; Brigham and Women's Hospital and Harvard Medical School. Department of Medicine. Channing Laboratory. Boston. MA. USA ; Harvard School of Public Health. Department of Biostatistics. Boston. MA. USA ; Harvard School of Public Health. Department of Epidemiology. Boston. MA. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 158, n° 8, 2003) |
Pagination : | 760-771 |
Langues: | Anglais |
Mots-clés : | Alcool ; Homme ; Femme ; Facteur risque ; Epidémiologie ; Cancer ; Appareil circulatoire [pathologie] ; Folate |
Résumé : | [BDSP. Notice produite par INIST-CNRS iciR0xwV. Diffusion soumise à autorisation]. Alcohol interferes with folate metabolism and has opposing effects on the risks of cardiovascular disease and cancer. The authors examined the joint association of alcohol and folate intake with risk of major chronic disease, defined as fatal or nonfatal cardiovascular disease or cancer, or other nontraumatic death. This study included 83,929 women aged 34-59 years with no previous history of cardiovascular disease or cancer who provided dietary data in 1980. During 16 years of follow-up, the authors documented 10,666 new cases of major chronic disease. Overall, heavy drinkers (>30 g/day) with a lower total folate intake ( |