Titre :
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Crohn's disease, ulcerative colitis, and measles vaccine in an English population, 1979-1998. (2003)
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Auteurs :
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V. SEAGROATT ;
M.J. GOLDACRE ;
University of Oxford. Department of Public Health. Unit of Health Care Epidemiology. Oxford. GBR
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Type de document :
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Article
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Dans :
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Journal of epidemiology and community health (vol. 57, n° 11, 2003)
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Pagination :
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883-887
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Langues:
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Anglais
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Mots-clés :
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Maladie Crohn
;
Vaccin
;
Homme
;
Rectocolite hémorragique
;
Virus
;
Rougeole
;
Virose
;
Infection
;
Vaccination
;
Prévention santé
;
Appareil digestif [pathologie]
;
Intestin [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST-CNRS AbR0xRm7. Diffusion soumise à autorisation]. Study objectives : To study the hospitalised incidence of Crohn's disease (CD) and ulcerative colitis (UC) from 1979 to 1998 ; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. Design : Analysis of linked data on hospital admissions ; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC ; and a comparison of these results with those from previous studies on the association between measles vaccine and CD or UC. Settings : Southern England. Subjects : People admitted to hospital with a main diagnosis of CD (1959 people) or UC (2018 people). Main results : Overall, the incidence of hospitalised CD showed no significant change over the 20 year period : the average change per year was 0.08% (95% confidence interval : - 0.7% to 0.9%). The relative risk associated with the measles vaccination programme was not significant (0.91 : 0.5 to 1.4). The estimate differed significantly from the relative risk of 3.0 obtained in the original study reporting an association, but agreed with the combined estimate from three subsequent studies (0.95 : 0.6 to 1.5). The results for UC were similar. Conclusions : The incidence of hospitalised CD and UC remained stable over the 20 years, 1979 to 1998. Whatever caused the marked increases in CD and UC in the mid-20th century must itself have stabilised in this region. These results, together with those from other studies, provide strong evidence against measles vaccine causing CD or UC.
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