Résumé :
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[BDSP. Notice produite par INIST-CNRS 8OHAR0xb. Diffusion soumise à autorisation]. Context : Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload. However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a healthy population. Objective : To examine plasma ferritin concentration and the ratio of the concentrations of transferrin receptors to ferritin in relation to risk of type 2 diabetes. Design, Setting, and Participants : 1989-1990 and were free of diagnosed diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. The controls (n=716) were matched to cases on age, race, and fasting status ; and on body mass index (BMI) for cases in the top BMI decile. Main Outcome Measure Incident cases of type 2 diabetes. Results : Among cases, the mean (SD) concentration of ferritin was significantly higher (109 [105] vs 71.5 [68.7] ng/mL for controls ; P<. for difference and the mean ratio of transferrin receptors to ferritin was significantly lower vs respectively p="01)." in conditional logistic regression stratified on matching factors controlled bmi other diabetes risk multivariate relative risks incident type across increasing quintiles were confidence interval cl trend rrs further adjustment an inflammatory marker protein did not change results appreciably. associations persisted within strata defined by levels menopausal status alcohol consumption c-reactive protein. conclusion : higher iron stores elevated concentration a are associated with increased healthy women independent known factors.>
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