Titre :
|
Influence of maternal human immunodeficiency virus (HIV) co-infection on vertical transmission of hepatitis C virus (HCV) : a meta-analysis : Infectious diseases. (2003)
|
Auteurs :
|
PAPPALARDO (Brandee-L) : USA. Blood Centers of the Pacific. Irwin Center. San Francisco CA.
|
Type de document :
|
Article
|
Dans :
|
International journal of epidemiology (vol. 32, n° 5, 2003)
|
Pagination :
|
727-734
|
Langues:
|
Anglais
|
Mots-clés :
|
Hépatite virale C
;
Virose
;
Infection
;
Mère
;
Hépatite virale A
;
Sida
;
VIH
;
Rétrovirus
;
Virus
;
VHC
;
Homme
;
Nouveau né
;
Femme
;
Epidémiologie
;
Immunopathologie
;
Appareil digestif [pathologie]
;
Foie [pathologie]
|
Résumé :
|
[BDSP. Notice produite par INIST-CNRS uR0xGyr5. Diffusion soumise à autorisation]. Background : Maternal co-infection with human immunodeficiency virus (HIV) has been implicated as a potentially important co-factor for enhanced vertical transmission of hepatitis C virus (HCV). In previous reports, however, methodological issues (notably small sample sizes) have limited accurate evaluation of the contribution of maternal co-infection with HIV on the risk of vertical transmission of HCV. Methods : A systematic review and subsequent meta-analysis of current published and unpublished reports was performed. Odds ratios (OR) and 95% CI for individual studies were calculated with maternal HIV serostatus as the exposure measure and HCV vertical transmission as the outcome measure. Overall summary estimates were then calculated using a random effects model that estimates a weighted average of OR from individual studies. Results : In total, 2382 infants from 10 studies were included in an analysis of HCV-infected mothers (defined by anti-HCV+antibody assays) with and without concomitant HIV infection. The risk estimate (OR) of HCV vertical transmission was 2.82 (95% CI : 1.78-4.45 ; P=0.00001) from anti-HCV+/HIV+co-infected mothers compared with anti-HCV+/HIV-mothers. In a subanalysis of 1327 infants born to viraemic (HCV RNA+) mothers, the risk estimate of HCV vertical transmission was 1.97 (95% CI : 1.04-3.74 ; P=0.04) from HCV viraemic/HIV+co-infected mothers compared with HCV viraemic/HIV-mothers. Conclusions : Results from this meta-analysis of observational studies suggest that the risk of HCV vertical transmission is higher in infants born to HIV co-infected mothers.
|