Résumé :
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[BDSP. Notice produite par INIST-CNRS NR0xkfQ8. Diffusion soumise à autorisation]. Context : Inflammation may play a role in the pathogenesis of colorectal cancer ; however, epidemiological evidence supporting this hypothesis in average-risk persons is sparse. Objective : To determine the risk of incident colon and rectal cancer associated with elevated baseline plasma concentrations of C-reactive protein (CRP). Design, Setting, and Participants : Prospective, nested case-control study of a cohort of 22887 adults (>18 years and Washington County, Maryland, residents) enrolled between May and October 1989 and followed up through December 2000. A total of 172 colorectal cancer cases were identified through linkage with the Washington County and Maryland State Cancer registries. Up to 2 controls (n=342) were selected from the cohort for each case and matched by age, sex, race, and date of blood draw. Main Outcome Measure Odds ratio (OR) of incident colon and rectal cancer. Results : Plasma CRP concentrations were higher among all colorectal cases combined than controls (median CRP, 2.44 vs 1.94 mg/L ; P=01). The highest concentration was found in persons who subsequently developed colon cancer vs matched controls (median CRP, 2.69 vs 1.97 mg/L ; P<. among rectal cancer cases crp concentrations were not significantly different from controls vs mg p="32)." the risk of colon was higher in persons highest lowest quartile confidence interval for trend="002)." nonsmokers corresponding association stronger ci a increase log associated with an increased after adjusting potential confounders and excluding occurring within years baseline cl or those late-stage at time diagnosis conclusions : plasma are elevated who subsequently develop cancer. these data support hypothesis that inflammation is factor development average-risk individuals.>
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