Résumé :
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[BDSP. Notice produite par INIST-CNRS iR0xEY58. Diffusion soumise à autorisation]. The association between androgen receptor gene polymorphisms and benign prostatic hyperplasia was investigated among 510 men randomly selected from Olmsted County, Minnesota. From 1990 through 2000, lower urinary tract symptom severity was assessed by the American Urological Association Symptom Index (AUASI), and peak urinary flow rate, prostate volume, and serum prostate-specific antigen level were measured. Androgen receptor CAG and GGN genotyping was performed. A CAG repeat length of1.4 ng/ml (HR=1.5,95% Cl : 1.1,2.0). A GGN repeat length of7 (HR=1.6,95% Cl : 1.1,2.3) and a serum prostate-specific antigen level>1.4 ng/ml (HR=1.5,95% Cl : 1.0,2.3). Having1.4 ng/ml (HR=2.8,95% Cl : 1.6,4.7), a peak flow rate7 (HR=1.6,95% Cl : 1.0,2.7). Androgen receptor gene polymorphisms may have a potential role in the pathogenesis of benign prostatic hyperplasia.
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