Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xZ01Q8. Diffusion soumise à autorisation]. The authors conducted a population-based, case-control study of 21,022 incident cases of 19 types of cancer and 5,039 controls aged 20-76 years during 1994-1997 to examine the association between obesity and the risks of various cancers. Compared with people with a body mass index of less than 25 kg/m2, obese (body mass index of>=30 kg/m2) men and women had an increased risk of overall cancer (multivariable adjusted odds ratio=1.34,95% confidence interval (Cl) : 1.22,1.48), non-Hodgkin's lymphoma (odds ratio=1.46,95% Cl : 1.24,1.72), leukemia (odds ratio=1.61,95% Cl : 1.32,1.96), multiple myeloma (odds ratio=2.06,95% Cl : 1.46,2.89), and cancers of the kidney (odds ratio=2.74,95% Cl : 2.30,3.25), colon (odds ratio=1.93,95% Cl : 1.61,2.31), rectum (odds ratio=1.65,95% Cl : 1.36,2.00), pancreas (odds ratio=1.51,95% Cl : 1.19,1.92), breast (in postmenopausal women) (odds ratio=1.66,95% Cl : 1.33,2.06), ovary (odds ratio=1.95,95% Cl : 1.44,2.64), and prostate (odds ratio=1.27,95% Cl : 1.09,1.47). Overall, excess body mass accounted for 7.7% of all cancers in Canada-9.7% in men and 5.9% in women. This study provides further evidence that obesity increases the risk of overall cancer, non-Hodgkin's lymphoma, leukemia, multiple myeloma, and cancers of the kidney, colon, rectum, breast (in postmenopausal women), pancreas, ovary, and prostate.
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