Titre : | Association between initial disease presentation, lung disease outcomes, and survival in patients with cystic fibrosis. (2004) |
Auteurs : | LAI (Hulchuan-J) : USA. Department of Nutritional Sciences. University of Wisconsin College of Agriculture and Life Sciences. Madison. WI. ; Philip-M FARRELL ; . HYUNGJUN CHO ; Michael-R KOSOROK ; . YU CHENG ; University of Wisconsin School of Medicine. Department of Biostatistics and Medical Informatics. Madison. WI. USA ; University of Wisconsin School of Medicine. Department of Pediatrics. Madison. WI. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 159, n° 6, 2004) |
Pagination : | 537-546 |
Langues: | Anglais |
Mots-clés : | Mucoviscidose ; Association ; Pronostic ; Evolution ; Survie ; Homme ; Diagnostic ; Symptôme ; Appareil respiratoire ; Epidémiologie ; Maladie héréditaire ; Symptôme respiratoire ; Appareil respiratoire [pathologie] ; Symptôme digestif ; Appareil digestif [pathologie] ; Métabolisme [pathologie] ; Pancréas [pathologie] |
Résumé : | [BDSP. Notice produite par INIST-CNRS tR0xo1yB. Diffusion soumise à autorisation]. This US study was conducted to determine whether mode of diagnosis and initial disease presentation influence lung disease and survival in patients with cystic fibrosis. The study population included 27,703 patients reported to the 1986-2000 Cystic Fibrosis Foundation Registry. Patients were segregated into four diagnostic categories : meconium ileus (MI), prenatal/neonatal screening (SCREEN), positive family history (FH), and symptoms other than meconium ileus (SYMPTOM). When compared with patients in the SCREEN group, those in the Ml or SYMPTOM group were found to have significantly greater risks of shortened survival, Pseudomonas aeruginosa acquisition, and forced expiratory volume in 1 second (FEV1) below 70% of predicted. In the SYMPTOM group, the greatest risks of shortened survival, P. aeruginosa acquisition, and FEV1 |