Titre :
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Obesity and the risk of Parkinson's disease. (2004)
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Auteurs :
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. HONGLEI CHEN ;
Alberto ASCHERIO ;
Miguel-A HERNAN ;
Michael-A SCHWARZSCHILD ;
Walter-C Willett ;
Shumin-M ZHANG
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 159, n° 6, 2004)
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Pagination :
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547-555
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Langues:
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Anglais
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Mots-clés :
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Obésité
;
Facteur risque
;
Risque
;
Maladie Parkinson
;
Etude prospective
;
Epidémiologie
;
Maladie nutrition
;
Maladie dégénérative
;
Système nerveux [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 7R0xTD51. Diffusion soumise à autorisation]. Dopamine is involved in the regulation of food intake, and obese persons have decreased dopamine D2 receptor availability in the striatum. Furthermore, midlife triceps skinfold thickness has been found to be positively associated with the risk of Parkinson's disease (PD) among Japanese-American men in Hawaii. The authors prospectively investigated whether obesity was associated with PD risk in two large cohorts of US men and women. They documented 249 cases of PD in men (1986-2000) and 202 cases in women (1976-1998). Neither baseline body mass index (weight (kg)/height (m) 2) nor early adult body mass index was associated with PD risk. The multivariate relative risk for a baseline body mass index of>=30 versus
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