Résumé :
|
[BDSP. Notice produite par INIST-CNRS R0xCgIwQ. Diffusion soumise à autorisation]. To investigate the potential effects of common early life exposures on age at menarche, the authors examined data collected in a follow-up study of pregnancies that occurred during the 1960s in California. Among 994 female offspring interviewed as adolescents, 98% had started their menstrual periods at a mean age of 12.96 years. After adjustment, the mean age at menarche was a few months earlier among girls whose mothers smoked a pack or more of cigarettes daily during pregnancy compared with unexposed girls (difference=-0.22 years, 95% confidence interval (Cl) : - 0.49,0.05) and more so among girls who were not White (difference=-0.52 years, 95% CI : - 1.1,0.08). Girls with both high prenatal and childhood passive smoke exposure had an adjusted mean age at menarche about 4 months earlier than those unexposed. The daughter's mean age at menarche varied little by maternal prenatal alcohol consumption. Daughters of tea consumers had a later mean age (difference=0.41 years at>=3 cups (0.7 liter)/day, 95% CI : 0.03,0.80) and were more likely to start menarche later (>13 years) (odds ratio=1.7,95% CI : 0.91,3.2), but daughters of coffee consumers did not. These suggestive findings, which merit further investigation, may be related to hormonal effects.
|