Titre :
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The association between HLA DQ genetic polymorphism and type 1 diabetes in a case-parent study conducted in an admixed population. (2004)
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Auteurs :
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Adriana MIMBACASL ;
Horacio CARDOSO ;
Rosario GRIGNOLA ;
Gerardo JAVIEL ;
Ana-Maria JORGE ;
Fernando PEREZ-BRAVO ;
Carmen PISCIOTTANO ;
José-Luis SANTOS ;
Hospital Pereira Rossell. Servicio de Endocrinologia Pediátrica. Montevideo. URY ;
Instituto de Investigaciones Biologicas Clemente Estable. Departamento de Citogenética. Montevideo. URY ;
Universidad de Chile Santiago. Instituto de Nutricion y Tecnologia de los Alimentos. Laboratorio de Epidemiologia Molecular. CHL
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 19, n° 10, 2004)
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Pagination :
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931-934
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Langues:
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Anglais
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Mots-clés :
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Association
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Génétique
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Maladie autoimmune
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Etude cas
;
Parent
;
Homme
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Uruguay
;
Amérique
;
Epidémiologie
;
Glande endocrine [pathologie]
;
Immunopathologie
;
Amérique du Sud
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Résumé :
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[BDSP. Notice produite par INIST-CNRS R0x4L391. Diffusion soumise à autorisation]. Susceptibility to the type 1 diabetes is genetically controlled and there is an increased risk associated with the presence of some specific alleles of the human leukocyte antigens class II loci (DQAI and DQB1 genes). The purpose of this study is to evaluate the association between type 1 diabetes and HLA DQ alleles using case-parents trios in the admixed population of Uruguay composed by a mixture of Caucasian, Amerindian and Negroid populations. DQAI and DQB1 genotyping was performed by polymerase chain reaction followed by oligospecific probes hybridization in 51 case-parents trios. The transmission disequilibrium test was used for detecting differential transmission in the HLA DQ loci. DQB1*0302 was the only allele for which preferential transmission is suggested (probability of transmission=67.56% ; exact p-value TDT=0.047 uncorrected for multiple comparisons). DQA1*0301 allele showed a trend for preferential transmission without achieving statistical significance. This result would confirm the hypothesis previously advanced in a case-control study. Therefore, DQB1*0302 allele could be considered as the most important susceptibility allele for developing type 1 diabetes in Uruguay population.
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