Titre :
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Smoking and the occurrence of Alzheimer's disease : Cross-sectional and longitudinal data in a population-based study. (1999)
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Auteurs :
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H.X. WANG ;
L. FRATIGLIONI ;
G.B. FRISONI ;
M. VIITANEN ;
B. Winblad ;
Department of Clinical Neuroscience and Family Medicine. Division of Geriatric Medicine. Karolinska Institute. Stockholm. SWE ;
Stockholm Gerontology Research Center. Stockholm. SWE
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 149, n° 7, 1999)
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Pagination :
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640-644
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Langues:
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Anglais
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Mots-clés :
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Démence Alzheimer
;
Tabagisme
;
Epidémiologie
;
Incidence
;
Prévalence
;
Facteur risque
;
Personne âgée
;
Homme
;
Suède
;
Europe
;
Système nerveux [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST iL2uwR0x. Diffusion soumise à autorisation]. The authors tested the hypothesis that smoking exerts a protective effect on Alzheimer's disease or dementia in a population-based cohort of 668 people aged 75-101 years (Sweden). Smoking was negatively associated with prevalent Alzheimer's disease (adjusted odds ratio=0.6,95% confidence interval 0.4-1.1) and dementia (adjusted odds ratio=0.6,95% confidence interval 0.4-1.0). Over 3-year follow-up (1989-1992), the hazard ratios of incident Alzheimer's disease and dementia due to smoking were 1.1 (95% confidence interval 0.5-2.4) and 1.4 (95% confidence interval 0.8-2.7). Mortality over 5-year follow-up was greater among smokers in demented (hazard ratio=3.4) than nondemented (hazard ratio=0.8) subjects. Smoking does not seem protective against Alzheimer's disease or dementia, and the cross-sectional association might be due to differential mortality.
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