Résumé :
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[BDSP. Notice produite par INIST-CNRS ZxiR0x3K. Diffusion soumise à autorisation]. Several reports have found a relation between polymorphisms of the vitamin D receptor gene (VDR) and the development of type 1 diabetes. We have examined the association of three VDR polymorphism with type 1 diabetes in 59 Chilean case-parents trios. Genotyping for Bsml, Apal and Taql polymorphism were performed. Transmission/disequiibrium tests were used to assess gene-disease associations through the evaluation of allelic transmission to affected offspring. Non-significant increased transmissions of B allele (probability of transmission=52.5%, p=0.69), A allele (probability of transmission=58.4%, p=0.17) and T allele (probability of transmission=52.0%, p=0.77) were estimated in Bsml, Apal and Taql sites, respectively. Haplotype-based analyses showed non-significant preferential transmissions (global p=0.52). The present study does not support the hypothesis of a significant contribution of VDR alleles in the etiology of type 1 diabetes of Chilean cases.
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