Titre :
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Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women. (2004)
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Auteurs :
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OROZCO (Pilar) : ESP. Cap Gòtic. Department of Family Medicine. University of Barcelona.
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 19, n° 12, 2004)
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Pagination :
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1105-1112
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Langues:
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Anglais
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Mots-clés :
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Hyperlipidémie
;
Lipide
;
Ostéoporose
;
Facteur associé
;
Association
;
Ménopause
;
Hypercholestérolémie
;
Femme
;
Homme
;
Cholestérol
;
Facteur risque
;
Epidémiologie
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Métabolisme [pathologie]
;
Système ostéoarticulaire [pathologie]
;
Hyperlipoprotéinémie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS LvRoR0xt. Diffusion soumise à autorisation]. Epidemiological studies have reported that women with osteoporosis present an increased risk of cardiovascular events and that lipid lowering therapy (statins) could be associated with a decreased risk of fracture. We investigated whether women with atherogenic lipid profile have lower lumbar and femoral bone mineral density (BMD) and higher prevalence of osteopenia than those with normal lipid levels. The study included 52 overweight early postmenopausal women, with no history of hormone replacement therapy, or any current or past pathology or treatment that could alter bone or lipid metabolism. Atherogenic lipid profile or hyperlipidemia was defined as hypercholesterolemia (>=240 mg/dl) or high low-density lipoprotein cholesterol (high-LDLc>=160 mg/dl) or high lipoprotein (a) [high-Lp (a)>=25 mg/dl], and low-BMD as t-score=240 mg/dl or LDLc>=160 mg/dl or Lp (a)>=25 mg/dl have lower lumbar and femoral BMD and have an increased risk of osteopenia than those with normal lipid profile, suggesting that hyperlipidemia could be associated with osteoporosis and bone status should be evaluated in women with hyperlipidemia.
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