Résumé :
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[BDSP. Notice produite par INIST-CNRS 9JR0xC8C. Diffusion soumise à autorisation]. The purpose of the present study is to examine HFE gene mutations in relation to newly diagnosed (incident) coronary heart disease (CHD). In a population-based follow-up study of 7,983 individuals aged 55 years and older, we compared the risk of incident CHD between HFE carriers and non-carriers, overall and stratified by sex and smoking status. HFE mutations were significantly associated with an increased risk of incident CHD in women but not in men (hazard ratio [HR] for women=1.7,95% confidence interval [CI] 1.2-2.4 versus HR for men=0.9,95% CI 0.7-1.2). This increased CHD risk associated with HFE mutations in women was statistically significant in never smokers (HR=1.8,95% CI 1.1-2.8) and current smokers (HR=3.1,95% CI 1.4-7.1), but not in former smokers (HR=1.3,95% CI 0.7-2.4). HFE mutations are associated with increased risk of incident CHD in women.
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