Titre : | Pooled analysis and meta-analysis of the glutathione S-transferase P1 lie 105Val polymorphism and bladder cancer : A HuGE-GSEC review. (2007) |
Auteurs : | Eliane KELLEN ; Karin BROBERG ; Frank BUNTINX ; Klaus GOLKA ; Marjolein HEMELT ; Rayjean-J HUNG ; . JIANHUA SHEN ; Vessela-Nedelcheva KRISTENSEN ; Giuseppe MATULLO ; Rama-D MITTAL ; Stefano PORRU ; Andrew POVEY ; Wolfgang-A SCHULZ ; Emanuela TAIOLI ; Maurice-P ZEEGERS ; Katholieke Universiteit Leuven. Comprehensive Cancer Institute. Department of General Practice. Limburg. BEL ; University of Birmingham. Department of Public Health and Epidemiology. Unit of Genetic Epidemiology. Birmingham. GBR |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 165, n° 11, 2007) |
Pagination : | 1221-1230 |
Langues: | Anglais |
Mots-clés : | Enzyme ; Homme ; Epidémiologie ; Maladie héréditaire ; Génétique ; Vessie ; Fer ; Appareil urinaire [pathologie] ; Cancer ; Enzymopathie ; Métabolisme [pathologie] ; Appareil urinaire |
Résumé : | [BDSP. Notice produite par INIST-CNRS ztzw6R0x. Diffusion soumise à autorisation]. The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GsTP1lle 105Val and bladder cancer, the authors undertook a meta-and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Valand Val/Val compared with GSTP1 lle/llewere 1.54 (95% confidence interval : 1.21,1.99 ; p |