Titre : | Prediction of coronary heart disease risk using a genetic risk score : The atherosclerosis risk in communities study. (2007) |
Auteurs : | Alanna-C MORRISON ; Lance-A BARE ; Eric BOERWINKLE ; CHAMBLESS (Lloyd-E) : USA. Collaborative Studies Coordinating Center. University of North Carolina. Chapel Hill. NC. ; James-J DEVLIN ; ELLIS (Stephen-G) : USA. Department of Cardiovascular Medicine. The Cleveland Clinic Foundation. Cleveland. OH. ; John-P KANE ; Mary MALLOY ; PANKOW (James-S) : USA. Division of Epidemiology and Community Health. University of Minnesota. Minneapolis. MN. ; James-T WILLERSON ; Celera. Alameda. CA. USA ; Texas Heart Institute. Houston. TX. USA ; University of California. Cardiovascular Research Institute. San Francisco. CA. USA ; University of Texas Health Science Center. Human Genetics Center. Division of Epidemiology. Houston. TX. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 166, n° 1, 2007) |
Pagination : | 28-35 |
Langues: | Anglais |
Mots-clés : | Cardiopathie coronaire ; Artériosclérose ; Facteur risque ; Génétique ; Etats Unis ; Amérique ; Appareil circulatoire [pathologie] ; Epidémiologie ; Homme ; Vaisseau sanguin [pathologie] ; Amérique du Nord |
Résumé : | [BDSP. Notice produite par INIST-CNRS OR0xoNLq. Diffusion soumise à autorisation]. Recent studies have evaluated whether incorporating nontraditional risk factors improves coronary heart disease (CHD) prediction models. This 1986-2001 US study aggregated the contribution of multiple single nucleotide polymorphisms into a genetic risk score (GRS) and assessed whether the GRS plus traditional risk factors predict CHD better than traditional risk factors alone. The Atherosclerosis Risk in Communities (ARIC) cohort was followed for a median of 13 years for CHD events (n=1,452). Individuals were genotyped for 116 single nucleotide polymorphisms associated with CHD in multiple case-control studies. Single nucleotide polymorphisms nominally predicting incident CHD in the ARIC study were included in the GRS. The GRS was significantly associated with incident CHD in Blacks (hazard rate ratio=1.20,95% confidence interval : 1.11,1.29) and Whites (hazard rate ratio=1.10,95% confidence interval : 1.06,1.14) as well as in each tertile defined by the traditional cardiovascular risk score (p |