Résumé :
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[BDSP. Notice produite par INIST-CNRS Ni4IR0xt. Diffusion soumise à autorisation]. The products of the renin-angiotensin system (RAS) play an important role in the pathogenesis of cardiovascular disease. Studies examining RAS gene variants and cardiovascular disease have focused on single-nucleotide polymorphisms (SNPs) rather than haplotypes, which better characterize the patterns of genetic variation. The authors conducted a population-based, case-control study at Group Health (Seattle, Washington) between 1995 and 1999 to determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angiotensin-converting enzyme gene, and the angiotensin II receptor type 1 and receptor type 2 genes were associated with the risk of myocardial infarction and stroke among pharmacologically treated hypertensive patients. SNP discovery was done using 23 European-origin samples. Thirty tagSNPs (the minimum sets of SNPs that capture most of the haplotype diversity within a block) were genotyped in cases and controls. Haplotypes were inferred using the program PHASE. The authors used weighted logistic regression to estimate associations and conducted a permutation test to estimate the probability of a chance finding. AGThaplotype B was associated with the risk of myocardial infarction (odds ratio=1.58,95% confidence interval : 1.06,2.35) ; however, results were not statistically significant given the number of tests performed (permutation p=0.17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke.
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