Résumé :
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[BDSP. Notice produite par INIST 9R0x1j5I. Diffusion soumise à autorisation]. Context Recent guidelines for treatment of overweight and obesity include recommendations for risk stratification by disease conditions and cardiovascular disease (CVD) risk factors, but the role of physical inactivity is not prominent in these recommendations. Objective To quantify the influence of low cardiorespiratory fitness, an objective marker of physical inactivity, on CVD and all-cause mortality in normal-weight, overweight, and obese men and compare low fitness with other mortality predictors. Design Prospective observational data from the Aerobics Center Longitudinal Study. Setting Preventive medicine clinic in Dallas, Tex. Participants A total of 25 714 adult men (average age, 43.8 years [SD, 10. 1 years]) who received a medical examination during 1970 to 1993, with mortality follow-up to December 31,1994. Main Outcome Measures Cardiovascular disease and all-cause mortality based on mortality predictors (baseline CVD, type 2 diabetes mellitus, high serum cholesterol level, hypertension, current cigarette smoking, and low cardiorespiratory fitness) stratified by body mass index. Results During the study period, there were 1025 deaths (439 due to CVD) during 258781 man-years of follow-up. Overweight and obese men with baseline CVD or CVD risk factors were at higher risk or all-cause and CVD mortality compared with normal-weight men without these predictors. (...)
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