Résumé :
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[BDSP. Notice produite par INIST 273R0xVa. Diffusion soumise à autorisation]. The authors examined the relation between age-related maculopathy and Alzheimer's disease in the Rotterdam Study, a prospective population-based study in the Netherlands. From 1990 to mid-1993, subjects aged 75 years or older (n=1,438) were screened for the presence of age-related maculopathy and Alzheimer's disease, and follow-up examinations were conducted from mid-1993 to the end of 1994. Subjects with advanced age-related maculopathy at baseline showed an increased risk of incident Alzheimer's disease (relative risk=2.1,95% confidence interval : 1.1,4.3 ; adjusted for age and gender), but this risk decreased after additional adjustment for smoking and atherosclerosis (relative risk=1.5,95% confidence interval : 0.6,3.5). These findings suggest that the neuronal degeneration occurring in age-related maculopathy and Alzheimer's disease may, to some extent, have a common pathogenesis.
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