Titre :
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GSTM1, smoking and lung cancer : a case-control study. (1999)
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Auteurs :
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I. STUCKER ;
P. BEAUNE ;
Jean Bignon ;
S. CENEE ;
I. DE WAZIERS ;
A. DEPIERRE ;
D. HEMON ;
B. MILLERON ;
Inserm U75. Hôpital Necker. Paris. FRA ;
Unité de Recherches Epidémiologiques et Statistiques sur l'Environnement et la Santé Epidemiologic and Statistical Research on Environment and Health Inserm U 170. Villejuif. FRA
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 28, n° 5, 1999)
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Pagination :
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829-835
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Langues:
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Anglais
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Mots-clés :
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Cancer
;
Poumon
;
Tabagisme
;
Génétique
;
Epidémiologie
;
Facteur risque
;
Homme
;
France
;
Europe
;
Appareil respiratoire [pathologie]
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Résumé :
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[BDSP. Notice produite par INIST yR0xrXBM. Diffusion soumise à autorisation]. Background We conducted a case-control study to examine the risk of lung cancer in relation to GSTMI polymorphism and cigarette smoking (primarily of black tobacco) in a French population. Methods The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on smoking history for all of them. Results presented here concern 247 cases and 254 controls. Results Taking non-or light smokers as the reference category, we estimated odds ratios (OR) of 4.2 (95% CI : 2.6-6.7) and 5.2 (95% CI : 3.3-8.3) for the medium and heavy smokers respectively. On the other hand we estimated that the crude OR associating GSTMI with lung cancer was 1.3 (95% CI : 0.9-1.8). Furthermore our data do not depart significantly from a multiplicative model of the combined effects of smoking and GSTM1 deficiency. Conclusions We conclude that smoking and the GSTM1 gene are each a risk factor for lung cancer, and that their combined effect does not differ significantly from that of a multiplicative model.
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