Résumé :
|
[BDSP. Notice produite par INIST R0xRjmD7. Diffusion soumise à autorisation]. Semen is the body fluid most commonly associated with sexual transmission of human immunodeficiency virus type-1 (HIV-1). Because the male genitourinary tract is distinct immunologically from blood, compartment-dependent factors may determine HIV-1 shedding in semen. To identify these factors, the authors obtained 411 semen and blood specimens from 149 men seen up to three times. Seminal plasma was assayed for HIV-RNA and semen was cocultured for HIV-1 and cytomegalovirus (CMV), which may up-regulate HIV-1 replication. The best multivariate model for predicting a positive semen HIV-1 coculture included two local urogenital factors, increased seminal polymorphonuclear cell count (odds ratio (OR)=12.6 for each log10 increase/mL, 95% confidence interval (Cl) 12.2,134.5) and a positive CMV coculture (OR=3.0,95% Cl 1.2,7.7). The best multivariate model for predicting semen HIV-1 RNA included two systemic host factors, CD4+cell counts
|