Titre :
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Influenza vaccines : Antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population. (1999)
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Auteurs :
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T. MENEGON ;
V. BALDO ;
C. BONELLO ;
D.D. COSTA ;
A. DI TOMMASO ;
R. TRIVELLO ;
Institute of Hygiene. University of Padua. Padua. IND ;
Public Health Department. Dolo Local Health District. Venice. ITA
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 15, n° 6, 1999)
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Pagination :
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573-576
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Langues:
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Anglais
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Mots-clés :
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Vaccination
;
Grippe
;
Virose
;
Infection
;
Anticorps
;
Examen sérologique
;
Plasma sanguin
;
Epidémiologie
;
Evaluation
;
Efficacité
;
Adulte
;
Homme
;
Italie
;
Europe
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Résumé :
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[BDSP. Notice produite par INIST jvR0x1BQ. Diffusion soumise à autorisation]. The humoral immune response generated by two commercial influenza vaccines was evaluated in a randomised, double-blind trial performed in the Public Department of Dolo Health District (Northeast Italy) during the winter season 1997-1998. Ninety-eight subjects were immunised with a split virus vaccine and ninety-six with a MF59-adjuvanted subunit virus vaccine (SU/MF59). The pre-and postvaccination (~30 days) antibody titres were determined by hemagglutination inhibition test (HI). After immunisation protective titre rates (>=1 : 40) were near 100% against virus A strain and 82.5% against B strain. Both vaccines caused significant rises in geometric mean antibody titres (GMTs) ; however, people who received SU/MF59 vaccine were found to develop a greater immune response compared to the group immunised with SVV. According to logistic regression analysis the unprotective prevaccination immune status and the use of SU/MF59 were identified as independent factors significantly increasing the response to immunisation.
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