Titre :
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Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. (2002)
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Auteurs :
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Jason-D MAGUIRE ;
Jkevin BAIRD ;
Michael-J BANGS ;
Budhi LAKSANA ;
Nurlis MAHMUD ;
Sofyan MASBAR ;
Purnomo PRODJODIPURO ;
Priyanto SISMADI ;
Iwa-W SUMAWINATA ;
I.K.A. SUSANTI ;
United States Naval Medical Research Unit 2. Jakarta. IDN
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Type de document :
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Article
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Dans :
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Lancet (The) (vol. 360, n° 9326, 2002)
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Pagination :
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58-60
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Langues:
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Anglais
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Mots-clés :
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Paludisme
;
Parasitose
;
Infection
;
Protozoaire
;
Epidémiologie
;
Asie
;
Homme
;
Indonésie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS mTgq3R0x. Diffusion soumise à autorisation]. Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malarlae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels (>=100 mug/L) on day 8 In both cases of persistent parasiotataemia. These findings suggest that clinical resistance to chloroquine by P malarlae occurs In the Indonesian archipelago of southeast Asia.
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