Titre :
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Gender-and race-specific determination of albumin excretion rate using albumin-to-creatinine ratio in single, untimed urine specimens : The Coronary Artery Risk Development in Young Adults Study. (2002)
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Auteurs :
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David-Rjr JACOBS ;
Frederick-C GOETZ ;
Maureen-A MURTAUGH ;
Jeffrey ROSEMAN ;
Michael STEFFES ;
XINHUA YU . (.)
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 155, n° 12, 2002)
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Pagination :
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1114-1119
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Langues:
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Anglais
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Mots-clés :
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Méthode
;
Urine
;
Albumine
;
Créatinine
;
Ratio
;
Age
;
Sexe
;
Jeune adulte
;
Homme
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Résumé :
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[BDSP. Notice produite par INIST-CNRS I7cgR0x6. Diffusion soumise à autorisation]. Although albumin excretion rate is commonly estimated by using albumin/creatinine ratio (A/C), gender and race differences in creatinine excretion may bias this estimate. The authors optimize the use of an untimed (spot) urine specimen among 3,371 Blacks and Whites aged 28-40 years in the Coronary Artery Risk Development in Young Adults Study in 1995-1996. Using three 24-hour collections during the year 5 examination, they determined k=0.68 x 0.88 in Black men, 0.88 in Black women, 0.68 in White men, and 1.0 in White women to reflect gender and race differences in creatinine excretion. The authors then computed A/C adjusted for race and sex differences in creatinine excretion (A/kC) by using an untimed urine sample in the year 10 examination. A/kC>=25 mg/g (194 cases of microalbuminuria and 26 cases of clinical grade albuminuria) was more common among Blacks (9.1%) than among Whites (4.2%) and among men (8.2%) than among women (5.0%). Use of the unadjusted A/C underestimated the prevalence of microalbuminuria among men by 52% and among Blacks by 26%. Adjustment of A/C permitted more accurate estimation of albumin excretion rate. Men and Blacks have a higher albumin excretion rate than do women and Whites and may thereby have an increased risk of microvascular and macrovascular disease.
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