Résumé :
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[BDSP. Notice produite par INIST NVuhHR0x. Diffusion soumise à autorisation]. Context Early-onset alcoholism differs from late-onset alcoholism by its association with greater serotonergic abnormality and antisocial behaviors, Thus, individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent. Objective To test the hypothesis that drinking outcomes associated with early vs late-onset alcoholism are differentially improved by the selective 5-HT3 (serotonin) antagonist ondansetron. Design Double-blind, randomized, placebo-controlled clinical trial. Settings University of Texas Health Science Center in Houston (April 1995-June 1998) and University of Texas Health Science Center in San Antonio (July 1998-December 1999). Participants A total of 321 patients with diagnosed alcoholism (mean age, 40.6 years ; 70.5% male ; 78.6% white) were enrolled, 271 of whom proceeded to randomization. Interventions After 1 lead-in week of single-blind placebo, patients were randomly assigned to receive 11 weeks of treatment with ondansetron, 1 mug/kg (n=67), 4 pg/kg (n=77), or 16 mug/kg (n=71) twice per day ; or identical placebo (n=56). All patients also participated in weekly standardized group cognitive behavioral therapy. Main Outcome Measures Self-reported alcohol consumption (drinks per day, drinks per drinking day, percentage of days abstinent, and total days abstinent per study week) ; and plasma carbohydrate deficient transferrin (CDT) level, an objective and sensitive marker of transient alcohol consumption. (...)
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