Résumé :
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[BDSP. Notice produite par INIST 5R0xNLUi. Diffusion soumise à autorisation]. The possibility that estrogen status modulates total homocysteine concentration, a risk factor for vascular occlusion, was examined in a representative sample of the US population, the Third National Health and Nutrition Examination Survey (phase 2), 1991-1994. The geometric mean serum total homocysteine concentration was compared among population subgroups differing on inferred estrogen status, after adjusting for potential confounding by age, race-ethnicity, smoking, and the serum concentration of creatinine, folate, and vitamin B-12. Premenopausal women aged 17-54 years had a lower mean serum total homocysteine concentration (8.1 mumol/liter, 95% confidence interval (Cl) : 7.9,8.2) than men in the same age range (8.9 mumol/liter, 95% Cl : 8.6,9.3). In the age range 17-44 years, pregnant women (6.0 mumol/liter, 95% Cl : 5.4,6.8), but not oral contraceptive users (7.9 mumol/liter, 95% Cl : 7.6,8.2), had a lower mean serum total homocysteine concentration than nonpregnant, non-oral-contraceptive-using women (8.1 mumol/liter, 95% Cl : 7.9,8.2). The mean serum total homocysteine concentration of estrogen-using women aged >=55 years (9.5 mumol/liter, 95% Cl : 8.9,10.1) was significantly decreased relative to nonestrogen users (10.7 mumol/liter, 95% Cl : 10.3,11.1) and men (10.4 mumol/liter, 95% Cl : 9.8,11.0) in the same age range. (...)
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