Titre :
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Cervical neoplasia and repeated positivity of human papillomavirus infection in human immunodeficiency virus-seropositive and - seronegative women. (2000)
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Auteurs :
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L. AHDIEH ;
A. MUNOZ ;
K. SHAH ;
L.A. TIMPSON ;
C.L. TRIMBLE ;
D. VLAHOV ;
Department of Epidemiology. School of Hygiene and Public Health. The Johns Hopkins University. Baltimore. MD. USA
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 151, n° 12, 2000)
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Pagination :
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1148-1157
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Langues:
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Anglais
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Mots-clés :
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Cancer
;
Virus
;
Séropositivité
;
Sida
;
Virose
;
Infection
;
VIH
;
Rétrovirus
;
Facteur risque
;
Homme
;
Femme
;
Immunopathologie
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Résumé :
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[BDSP. Notice produite par INIST R0xJZLGg. Diffusion soumise à autorisation]. Increased risk for cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV) - infected women may be explained by repeated positivity of human papillomavirus (HPV) infection facilitated by HIV infection and related immunosuppression. As part of a longitudinal study with semiannual examinations, 268 women in Baltimore, Maryland (of whom 184 were HIV+), provided 1,426 cervicovaginal lavage specimens tested for HPV DNA by a polymerase chain reaction-based assay between 1992 and 1998. HPV positivity and time to HPV clearance according to HIV serostatus and CD4+cell count were compared using models for correlated binary data and survival analysis. Of the 187 participants who had at least one positive measurement, the probability of subsequent HPV positivity among HIV-women and HIV+women with CD4+>200 and=200 and
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