Titre : | Determining the effect of highly active antiretroviral therapy on changes in human immunodeficiency virus type 1 RNA viral load using a marginal structural left-censored mean model. (2007) |
Auteurs : | COLE (Stephen-R) : USA. Department of Epidemiology. Bloomberg School of Public Health. Johns Hopkins University. Baltimore. MD. ; ANASTOS (Kathryn) : USA. Montefiore Medical Center. Bronx. NY. ; Miguel-A HERNAN ; JAMIESON (Beth-D) : USA. Department of Medicine. David Geffen School of Medicine. University of California. Los Angeles. Los Angeles. CA. ; ROBINS (James-M) : USA. Department of Biostatistics. School of Public Health. Harvard University. Boston. MA. |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 166, n° 2, 2007) |
Pagination : | 219-227 |
Langues: | Anglais |
Mots-clés : | Sida ; Thérapeutique médicamenteuse ; Chimiothérapie ; Médicament antirétroviral ; Traitement antirétroviral ; Médicament antiviral ; Changement ; Thérapeutique ; Biais ; Epidémiologie ; Homme ; Virose ; Infection ; VIH ; Rétrovirus ; Virus ; Immunopathologie |
Résumé : | [BDSP. Notice produite par INIST-CNRS mR0x1xwD. Diffusion soumise à autorisation]. Highly active antiretroviral therapy (HAART) dramatically reduces the load of circulating human immunodeficiency virus type 1 (HIV-1) by blocking replication at multiple points in the viral life cycle, but the long-term effect of HAART on viral load remains unclear. In the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study, 918 HIV-1 - infected men and women who were not using antiretroviral therapy were followed for a median of 5.8 years between 1996 and 2005. Follow-up yielded 3,629 person-years of observation, during which 286 (31%) of the participants initiated HAART. A marginal structural left-censored linear model for semiannual repeated assessments of viral load showed a 1.9 log10 decrease in viral load after HAART initiation as compared with nonuse (95% confidence interval : 1.7,2.2), which remained stable over the course of follow-up but was stronger among men (interaction p |