Titre : | Dietary fatty acids and colorectal cancer : A case-control study. (2007) |
Auteurs : | Evropi THEODORATOU ; Rebecca BARNETSON ; Harry CAMPBELL ; Roseanne CETNARSKYJ ; Malcolm DUNLOP ; Susan-M FARRINGTON ; MCNEILL (Geraldine) : GBR. Environmental and Occupational Medicine Department. University of Aberdeen. Aberdeen. ; Mary PORTEOUS ; Albert TENESA ; Colon University of Edinburgh. Western General Hospital. Cancer Genetics Group. Edinburgh. GBR ; University of Edinburgh. Public Health Sciences. Edinburgh. GBR ; Western General Hospital. South East Scotland Genetic Service. Edinburgh. GBR |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 166, n° 2, 2007) |
Pagination : | 181-195 |
Langues: | Anglais |
Mots-clés : | Alimentation ; Aliment ; Régime alimentaire ; Acide gras ; Enquête cas témoin ; Epidémiologie ; Logistique ; Modèle ; Ecosse ; Homme ; Grande Bretagne ; Royaume Uni ; Europe ; Lipide ; Appareil digestif [pathologie] ; Intestin [pathologie] ; Cancer |
Résumé : | [BDSP. Notice produite par INIST-CNRS uz9R0xb3. Diffusion soumise à autorisation]. Fatty acid effects on colorectal cancer risk were examined in a national prospective case-control study in Scotland (1999-2006), including 1,455 incident cases and 1,455 matched controls. Three conditional logistic regression models adjusted for energy (residual method) and for other risk factors were applied in the whole sample and were stratified by sex, cancer site, age, and tumor staging. Total and trans-monounsaturated fatty acids and palmitic, stearic, and oleic acids were dose-dependently associated with colorectal cancer risk, but these effects did not persist after further energy adjustment. Significant dose-dependent reductions in risk were associated with increased consumption of omega-3 polyunsaturated fatty acids (highest vs. lowest quartile of intake : odds ratio=0.63,95% confidence interval : 0.50,0.80 ; p |