Résumé :
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[BDSP. Notice produite par INIST R0xsk1vt. Diffusion soumise à autorisation]. To evaluate a possible association between varicella-zoster virus infection and glioma, the authors asked adults with glioma (n=462) whose tumors were diagnosed between August 1,1991, and March 31,1994, and age-sex-and ethnicity-matched controls (n=443) about their histories of chickenpox or shingles. Cases were significantly less likely than controls to report a history of either chickenpox (odds ratio=0.4,95% confidence interval (Cl) 0.3-0.6) or shingles (odds ratio=0.5,95% Cl 0.3-0.8). To obtain serologic support for these findings, the authors conducted double-blind enzyme-linked immunosorbent assays for immunoglobulin G antibodies to varicella-zoster virus among 167 self-reporting subjects for whom blood samples were available. Cases and controls reporting no history of chickenpox were equally likely to test positive (73% vs. 75%), but among those reporting a positive history, cases were less likely than were controls to test positive (71% vs. 85%). Despite the misclassification, an odds ratio of 0.6 was obtained using either serologic data (95% Cl 0.3-1.3) or reported history of chickenpox (95% Cl 0.3-1.1) in this subgroup of subjects. This suggests that adults with glioma were less likely than controls either to have had prior varicella-zoster virus infection or to have an immunoglobulin G antibody response adequate to indicate positivity. (...)
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