Résumé :
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[BDSP. Notice produite par INIST R0x44w1T. Diffusion soumise à autorisation]. Background. In Orebro County a 2.5-fold increase in the incidence of Haemophilus influenzae (HI) meningitis was found between 1970 and 1980, an observation that initiated the present study. Materials and methods. In order to search for associations between morbidity in invasive HI infection and possible risk factors, a case-control study was conducted over a 6-year period from 1987 to 1992, before general Hib vaccination was introduced in Sweden. Fifty-four cases with invasive HI infection and 139 matched controls were studied for possible risk factors such as day-care outside the home, short duration of breastfeeding, passive smoking, low socioeconomic level of the household, many siblings in the family, allergy, frequent infections, repeated antibiotic treatments and immunoglobulin deficiency. Results. Multivariate analysis showed a significant association between invasive HI infection and two independent factors, i.e. short duration (
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