Résumé :
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[BDSP. Notice produite par INIST H4R0xVbY. Diffusion soumise à autorisation]. Background. Based on the increased consumption of alcohol in Denmark the aim of this study was to measure prevalence of abnormal liver-derived enzymes in a homogeneous Danish population and possible associations with alcohol consumption, smoking and body mass index (BMI). Method. In a representative population sample of 905 people (aged 30-50) from the baseline survey of the Ebeltoft Health Promotion Project in Denmark, we examined prevalence of abnormal liver-derived enzymes and its possible association with self-reported alcohol consumption, smoking and BMI, applying logistic regression analyses. Results. In a significant proportion, 12% (women 8% ; men 16%) of the cohort we found raised levels of liver-derived enzymes associated with moderate self-reported alcohol intake adjusted for BMI and smoking. If the intake was higher than moderate, i.e.>28 units per week (one unit equals 12 g of alcohol), the odds ratio (OR) for raised liver enzymes increased further ; S-gamma-glutamyltransferase (GGT) (OR : for women 24.4 ; men 18.4), S-aspartate-aminotransferase (ASAT) (24.2 ; 5.8) and S-alanine-aminotransferase (ALAT) (27.2 ; 3.0). Furthermore, daily smoking increased the risk of raised liver enzymes in women (OR : 3.4-4.2), and obesity (BMI 30 kg/m2) in men showed a positive association with all three enzymes (OR : 3.0-9.0). Conclusions. (...)
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