Résumé :
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[BDSP. Notice produite par INIST yyR0xysf. Diffusion soumise à autorisation]. Background. Intermittent claudication is associated with a poor prognosis, but less is known of the risks associated with asymptomatic peripheral arterial disease. The aims of this study were to determine the incidence and natural history of claudication, and the incidence of cardiovascular events in symptomatic and asymptomatic peripheral arterial disease. Methods. In 1988,1592 subjects aged 55-74 years were selected randomly from the age-sex registers of 10 general practices in Edinburgh, Scotland. The presence of peripheral arterial disease was determined by the World Health Organization questionnaire on intermittent claudication, the ankle brachial pressure index and a reactive hyperaemia test. This cohort was followed prospectively over 5 years for subsequent cardiovascular events and death. Results. One hundred and sixteen new cases of claudication were identified (incidence density 15.5 per 1000 person-years). Of those with claudication at baseline, 28.8% still had pain after 5 years, 8.2% underwent vascular surgery or amputation, and 1.4% developed leg ulceration. audicants had a significantly increased risk of developing angina compared with normals (RR : 2.31,95% CI : 1.04-5.10), and asymptomatic subjects had a slightly increased risk of myocardial infarction and stroke. Deaths from cardiovascular disease were more likely in both claudicants (RR : 2.67,95% CI : 1.34-5.29) and subjects with major (RR : 2.08,95% CI : 1.13-3. (...)
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